/sci/ - Science & Math

[Anonymous No.12026410]

Memes aside, how long until we get genetic modification (both cosmetic and functional) do you think?

[Anonymous No.12026524]

>>12026410
Anytime

There is nothing stopping it happening
The tech is here

Grab your destiny

[Anonymous No.12026534]

>>12026410
>>12026524
Maybe, but not likely for a very long time: You induce cumulative pleiotropic mutations for each intended mutation to the genome, and often these mutations are not beneficial, but instead detrimental. In other words, to have such extreme control over the genome, without inducing such catastrophic cumulative pleiotropic mutations you also need to improve your predictive powers. So, until we have a computer revolution, we wont have a genetic revolution.
Incidentally, I'm so fucking sick of you IFLS retards who watch a Kurzgesagt video and suddenly consider themselves some visionary expert. Fuck off.

[Anonymous No.12026540]

China will be the first country where cybernetics will thrive first, since they are averse to morals.
Nothing is there to stop it, especially since there is barely anything good left in the mean of humankind to begin with.
All that's left is misery.

[Anonymous No.12026550]

>>12026540
Biotech will dominate before cybernetics, you retard. At the moment, cybernetics can't even compete with natural organs and limbs, let alone better it. Also, until we have things like self-healing and adaptive materials, biotech will still be more powerful, because it will be more versatile.

[Anonymous No.12026555]

>>12026550
but cybernetics will surely thrive first in the transhumanist tragedy, no?
Biologists are too dumb to replace electronics that quickly.

[Anonymous No.12026572]

>>12026555
Have the fuck are you going on about? Biotechnology and medical science is already way ahead of cybernetics, until we have a revolution in materials science, biological material is innately superior because it repair from stress, can adapt to stress, etc.
We struggle to make robots that suit one purpose, let alone robots that are nearly as versatile as an organism.

[Anonymous No.12026577]

>>12026572
>*it can repair

[Anonymous No.12026603]

>>12026572
If you are to surpass humanity, these materials will have to be logically manipulitable, such as how logics circuits are built.
I am not entirely sold on the idea of stem cell therapy or the like. The material to be worked with is far too unstable. At the very best, designer babies present themselves more viable.
As previously mentioned, only the Chinese would tolerate such discretion upon man.

[Anonymous No.12026624]

>>12026555
cybernetics will be used for neural interface and some brain enhancments, the rest of the stuff is way easier to fix or enhance with biotech

[Anonymous No.12026748]

>>12026534
You’re afraid of progress

[Anonymous No.12026758]

>>12026534
Those who get genetic modification could be “neutered” in order to prevent their new spooky genes from spreading.
That would be a high price to pay for a pair of cat ears though.

[Anonymous No.12026785]

>>12026410
We could do it now: https://www.technologyreview.com/2019/02/21/137309/the-crispr-twins-had-their-brains-altered/,but obvious gene modification will need around 30 years to become a reality.
Accurate prediction of height from genome has already been accomplished, identifying 10k positively associated loci (https://www.biorxiv.org/content/biorxiv/early/2017/09/18/190124.full.pdf).). Genetic architecture of intelligence is similar to that of height (https://arxiv.org/pdf/1408.3421.pdf).). It is only a matter of time before enough genotype-phenotype pairs are collected to perform a similar analysis on cognitive ability, and identify the estimated 10k SNPs that explain the variance in IQ. After these are identified, an optimized genotype could be discovered and implemented in human embryos via genetic engineering, although the technology here will also have to advance to be able to edit 10k loci reliably. Thus it could be possible to breed the first augments in 10~15 years.

[Anonymous No.12026791]

>>12026748
Not in the fucking slightest, I'm a biogerontologist.
My issue is thus:
Before it is possible it'll require a REVOLUTION in both computer science and genetic engineering, that's two whole fields, before it is even feasible. OP is focusing on the wrong things, it is nothing more than a distracting pleasant pipe dream. You don't change the world by dreaming, you change the world by doing. So, if you're dreaming about doing the wrong thing, in the wrong way... guess what? You aren't being helpful, nor insightful, at all.
Focus on problems we can tackle, before trying to tackle problems before we even have solutions to their antecedents. It's pretty fucking obvious.

[Anonymous No.12026798]

>>12026758
They'd probably be nonviable, from the sheer deleterious genetic load.

[Anonymous No.12026799]

Depends on the degree you want to do it, I suspect we need another 15 years to disentangle the entire mess of spaghetti code that is DNA, and not just figuring out what the code says, but really figuring out how it works. If we have done this, we could modify, for example, the GRIN2B (https://www.ncbi.nlm.nih.gov/pubmed/19838302)), the PDE4B (https://www.ncbi.nlm.nih.gov/pubmed/?term=26272049)), https://www.ncbi.nlm.nih.gov/pubmed/25225386 and the FOXP2 strains (https://www.ncbi.nlm.nih.gov/pubmed/19838302)) to help our children to have more potential. Add modifications with TP53, CDKN2A, CTNNB1, NGF, MSTN, EPOR and APOE genes, and you got the basis for a healthy, fit and smart child. I could imagine that in 30 years, genetic modifications might be common enough, the new vaccine to help your child have a better health, fitness and intelligence so that it has more autonomy.
As an advise for anyone to excited about these developments, genetic modifications alone will not make a happy, smart and healthy child. Genetic modifications change the possibilites on how genes express themselves, not make one child a super-human. Love, education and a good enviroment will be necessary to help it further. Genetic modifications can be used to support your child even more, but even a baby that was geneticaly modified will crap his pants, moan that it want stay awake longer (and with modifications of the NPSR1, BHLHE41 and ADRB1 allells it will might only need 4 hours of sleep, though luck for parents) and need to be protected from danger.

[Anonymous No.12027014]

>>12026791
You seem to have some kind of alternative issue to be this obsessed while being wrong

[Anonymous No.12027029]

>>12027014
Whoa, nice non-argument. I see all of that lack of reasoning, very impressive. How about you take a moment, have a little think and come back, champ?

[Anonymous No.12027033]

>>12027029
No. I’m made my point you’re stuck on.

[Anonymous No.12027042]

>>12027033
But you didn't, you claimed something, without reason, or evidence, as to why it was true.
How am I wrong?

[Anonymous No.12027044]

>>12026524
>>12026748
>>12027014
>>12027033
Cringe, shut the fuck up now before you embarass yourself further
>>12026534
>>12026791
>>12027029
Based

[Anonymous No.12027069]

>>12027042
>>12027044
Obsessed
Somethings amiss here

[Anonymous No.12027079]

>>12027069
>Made one (1 (uno (I))) post
>obsessed

[Anonymous No.12027095]

>>12027069
Not me, fag. You're just unpopular.

[Anonymous No.12027103]

Can anyone specifically estimate how long it might be before this can be useful for currently-living adults, rather than just doing the modification on embryos (or zygotes or whatever)?

[Anonymous No.12027115]

>>12027103
Within n+1 years, where n is the theoretical time until full-scale genetic modification.

[Anonymous No.12027132]

>>12027103
Well, you gonna need specialised retrovirusis or nanomachines to genetically modify humans. It would be easier to implant new organs into adult bodies.
Implants would require around 20 years to be publically avaible. Retroviral treatments will atleast need 50 years to become feasible.

[Anonymous No.12027141]

>>12027132
>Retroviral treatments will atleast need 50 years to become feasible.
>... 50 years...
>25+50=75
Fucking hell, I hope we get some meaningful progress in biogerontology before then.

[Anonymous No.12027150]

>>12027132
That's about what I figured, yeah. Though I'm not sure how useful organ implants would be, since I figure the goal would be to change the genome of almost every cell in the body, or at least a high percentage of certain kinds of cells, rather than just the cells in one or a few particular organs.

I wonder if it'll become accessible during the lifetime of anyone reading this thread. Who knows, maybe we'll advance nanotechnology or programmable viruses faster than we advance the actual gene manipulation part (for complex polygenic traits like intelligence; single-gene switches probably won't be too hard), so maybe the bottleneck will be the gene research side.

Maybe near-future advances in AI we can't currently foresee will speed both fields up, as well. Gene research seems like something fairly well-suited for machine learning, though the bottleneck there will probably still be doing the actual tests in accurate models. The information and computation side may become very fast, but AIs can't just spit out trillions of mouse or human embryos and test them all in parallel.

[Anonymous No.12027158]

>>12026748
fucking tranny join the 41% club already

[Anonymous No.12027162]

>>12027132
>>12027150
Also, if you're implanting foreign objects into the body, especially biological organs with a foreign genome, wouldn't you essentially need to be on immunosuppressants?

[Anonymous No.12027190]

>>12027141
Retroviral treatment aren't the only way for gene therapy but the most powerful one. Life extension technologies will be avaible in this centuries half but rejuvenation will only be possible via retroviral treatments.
www.cell.com/cell/abstract/S0092-8674(16)31664-6?_returnURL=http%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0092867416316646%3Fshowall%3Dtrue

[Anonymous No.12027200]

>>12027162
Indeed, but one could bio-print organs with your DNA in the not too far future. They would be accepted by it, in fact "wet" nanomachines in the form of nanosymbionts could also be injected into the body around 30 years or so.

[Anonymous No.12027210]

>>12026534
incredibly based. pop sci retards itt are what is ruining /sci/

[Anonymous No.12027218]

>>12027190
So, there is decent likelihood I'll live to see this future, and greater futures?

[Anonymous No.12027253]

>>12027218
If you keep up a healthy life style, earn enough money and the political/economic values stay/focus more on humanist ideas then yes. A transhuman future might be possible for you.

[Anonymous No.12027261]

Let’s make it happen.

Everyone that ignores people giving complaints instead of solutions is a god,

[Anonymous No.12027265]

>>12027253
>If you keep up a healthy life style...
Guess I'd better start doing cardio, lifting and stretching, while improving my diet.
>... earn enough money...
Sucks to be a research monkey then.
>... and the political/economic values stay/focus more on humanist ideas...
I have a feeling that they will, even the contemporary right is humanist, although in a more tribalistic, protectionist sense, and I doubt the left would radically change in that regard. Although I'm neither, I'm one of those fence-sitting centrists, because I believe in the golden mean.
>A transhuman future might be possible for you.
Something to look forward to, I hope. It certainly alleviates my thanatophobia somewhat, thank you.

[Anonymous No.12027288]

>>12027261
just ignoring the problems makes you a fool. You won't become a god by ignoring the problems.
>>solutions
would address the problems mentioned. Biology is hard. As an example of how biology is hard, only 13%;of treatments that make it to late stage clinical trials are effective. So after all the tube tests we've done, tests in mice, and tests in small numbers of people, almost 9 times out of 10, it just fails. This because we don't really understand biology all that well.

[Anonymous No.12027361]

>>12026410
I mean, there's one thing to do it, it's another to do it well. We can do it right now, but considering our level of understanding of genomes, augmenting one thing will just fuck another thing up. That's what happens when you don't know all the variables- some loose string ends up biting you in the ass.

Ex- you can't cure cancer, but you can make the body more resilient. Well that would make the body's processes entirely more energy draining, and now we have extra dietary needs but didn't take into account that all those extra sugars are gonna give us diabetes by age 20.

[Anonymous No.12027429]

>>12026791
I mean I do a lot of comp bio. The problems you are referencing are already solved on a theoretical/computational level. They aren't even that complicated. What is complicated is making sure that the mutations induced aren't too gnarly after the fact. So implanting something we modified is way easier then just inducing a modification.

We need revolution in stem cell tech, not computer science. Computer science will be what we use to crack the biophysics of the cell and the more complex organ creation processes though.

[Anonymous No.12027450]

>>12027429
I'm talking about genetic engineering on the scale of catgirls and sort of almost complete transformations that people like to meme about on /sci/. You can't just trial and error something that whole.

[Anonymous No.12028482]

>>12027450
>You can't just trial and error something that whole.
Well, you could but it wouldn`t be ethical thus China will develop it first.

[Anonymous No.12029121]

EVERYONE IN THIS THREAD WILL TAKE THEIR LAST BREATH. TRANSHUMANISM IS A MEME

[Anonymous No.12029203]

>>12027288
I don’t think you understand biology well

[Anonymous No.12029233]

>>12029121

[Anonymous No.12029237]

>>12029121
Humans are robots

So transhumanism makes sense

[Anonymous No.12029531]

>>12029237
who is that girl

[Anonymous No.12031477]

>>12029531
Stop being a coomer
https://forum.nofap.com/index.php?threads/6-years-clean-rebooting-as-the-best-remedy.135983/

[Anonymous No.12032443]

[Anonymous No.12032452]

>>12029203
>pic
holy based

[Anonymous No.12032827]

Unles Super AI (Machine God) comes along, probably never.
You have no idea how hard it is, genetics wise, to create something akin to cat ears and cat tails on a human body. It's so hard in fact, that creating a superhuman being with infinite IQ would be easier. To create "on-demand" cosmetic thought-up features like this would require computation power big enough to run billions of genetic simulations per second or a god that understands genetics on the particle level.
I am sorry to tell you, but unless Super AI comes along, there's no way biological catgirls will ever be a thing. It's but a fantasy in the realms on sci-fi only.

Other than that, doing shit like changing hair/eye color and certain other things we already have genetic recipe for is trivial and could be done even today.

[Anonymous No.12033190]

>>12032443
Based drakaposter

[Anonymous No.12033259]

>>12026410

[Anonymous No.12033293]

>>12026410
we couldn’t even handle having different skin colors, facial features, and hair textures. this will be a catastrophe