/lit/ - Literature

>>13543735
yeah and it btfos them too, this dingus posted the link without reading it, probably got it from some reddit porn board

>Our premise is that selective atrophy of cortical areas associated with reward pathways may be viewed in a neuromodulatory light, given current research confirming neuroplasticity in overindulgence in natural rewards, specifically sexuality. The inability of those challenging our conclusions to understand even the most basic of these concepts is illustrated by their comments about specific processes. For instance, their dismissal of the importance of ΔFosB is illustrated by their manifest lack of insight into the research concerning this protein. While mentioning that stress can induce ΔFosB, they fail to understand that the pattern of expression with stress extends broadly across both dynorphin+ and enkephalin+ medium spiny neurons and is not confined to dynorphin+ medium spiny neurons as it is in the overexpression associated with overconsumption of natural rewards and with drug addiction.[24] The following comment is illustrative of their lack of understanding the importance of ΔFosB as a molecular switch in addiction: “That's great news for the sexually inexperienced rats! Put your name on the list for more ΔFosB and your sexual performance will be on par with more experienced rats.” They correctly point out that atrophy is associated with aging, and may be affected by comorbidities, neurotoxicity, and the like, but fail to appreciate selective atrophy in cortical areas associated with reward centers. The concept of upstream neuronal atresia as illustrated in figure 2 in the Nestler paper, focusing on a common pathway for drug and natural addiction,[23] may be an important mediator in this process. This atresia is associated with decreased dopaminergic input into the NA from the VTA, and with decreased glutaminergic input from the cortex, both being associated with an increase in ΔFosB in the medium spiny neuron. The cortex can atrophy in response to decreased downstream stimuli.[21] That there is a functional frontal deficit in addiction is the hallmark, whether drug induced or naturally induced, and the hypofrontal syndrome displayed is similar to that seen in traumatic brain injury.[16] Another recently reported example of selective cortical atrophy in reward-associated regions in adolescents manifesting Internet “addiction” is of interest in this context.[34]

>While a role for inherency is obvious, to deny any role for causation is to envision a world of selectively preatrophied individuals destined to act out in addiction. We find this premise much less plausible than at least a partial role for causation given what we consider confirmatory data with regard to the role of ΔFosB in the induction and then perpetuation of addictive states.

tl;dr stop watching porn

and use 4chan less