/biz/ - Business & Finance

>>18191586
Corona is already solving that problem

Wtf bros is he trying to live forever so he can rule the world?

>>18191586
I like that people immediately got mad at him for trolling. Vitalik is such a weird dude. His IQ is too high for this Earth.

>>18191627
his end goal is to upload his consciousnesses to quantum enabled ETH3.0 and unironically live on the blockchain

>>18191647
It’s bizarre how disconnected normies are from this concept. Age reversal will be here by 2060 max. More likely 2040s

>>18191647
>for trolling

>>18191696
I'm a computational biologist and I work in age reversal but it's really not that simple. Virtually all companies that claim to be into that shit are stuck working on better (((anti-aging face cream))) and other bullshit. There are many known immortal living organisms, going from nematodes to weird serbian blind moles to jellyfishes, but almost nobody is doing comparative genomics or proper proteomics or even proper rna-seq analysis, it's almost exclusively dumb drug assays and handwaving.

>>18191666
There is already a vishnu on the blockchain

>>18191879
Guys like de Grey (who seems a bit sketchy desu) and George Church (who seems pretty legit) are saying it’s less than 20 years away.

How did you get into that stuff anon? What do you think the timeline is?

>>18191976
People give numbers all the time. They're always wrong, with no relation to credentials, regardless of fields. In anti-aging research, people have been saying 'it's just 20 years away' for many decades now.
I got into it because I figured that almost anything I want to do would only be possible by either becoming a billionaire or becoming immortal, and beside, there are endless things to do if you don't die. I made that judgement long ago.
The state of these things has never been too hopeful so instead of going biology, I went computer science, since in the worst case it would speed up progress in the biology side. Then the whole big data bullshitery hit and I was perfectly placed to take advantage of it. It also turned out that research in the biology side is even worse than I once thought - extremely little formalism, p-hacking and data manipulation everywhere, jumping to conclusions based on next to nothing-tier anecdotal nonsense. Quant disciplines surrounding biology are MUCH better and have been the main driver behind much of modern advancements.
In a word: right place right time and even more luck.
Still, at the current rate, I don't see any meaningful advances in anti-aging for the next 80 years, and this assumes at least one major breakthrough.

What about your brain though?
Times speeds up as you get older.
If you lived 500 years youd experience 1 hour in a day or some whacky shit.

>>18192442
I think that’s because you’re aging. If you somehow reversed all of the hallmarks of aging it seems logical that you might experience time more slowly.

>>18191696
Will result in civil war.

>>18191696
Age reversal is next century

>>18191885
Vitalik will become the Shiva on the blockchain

OH SURE, LET'S JUST MAKE THE BOOMERS SCREWING US OVER DAILY BECOME IMMORTAL SO WE CAN WAGESLAVE FOR THE REST OF OUR LIVES.

WHO'S WITH ME?

>>18191586
he really is a fucking commie

>>18192398
>Still, at the current rate, I don't see any meaningful advances in anti-aging for the next 80 years, and this assumes at least one major breakthrough
I dunno anon it seems like the past 2 years has seen exponential growth in funding and research. Are you in America? Do you know who these guys are that I’m talking about? They’re well respected in the field. I can’t imagine more than 40 years before some sort of major breakthrough that buys us enough time to make it 40 more years. Senolytics, telomere lengthening, and in general addressing the 8-9 hallmarks of aging, which didn’t even exist formally until the 2000s. I think you’re being a little pessimistic. I would have agreed with you 5 years ago but this is picking up serious steam hence guys like Vitalik bringing it up and advocating for it

>>18192555
It's because reference. If you already lived a 100 years a day seems way less than when you are 5 years old and it is a significant chunk of time in your life, in comparison. No pill or treatment would help it. And if we are already at it, disguising fear of death as science or progress is disgusting and repulsive even for you anons. I hope covid-69 kills us all before some faggot comes up with the idea.

>>18192555
No it’d make it worse. When you’re young each year is a larger proportion of your total life. As you get older that percentage gets smaller and smaller and plus there’s less novel experiences (the stuff you remember). After 1000 years days would pass like minutes, there’s be nothing new to see or do and every year would be a minuscule percentage of your total life.

As for me I don’t want to be stuck in space and time any longer than I have to

>>18192398
last i heard they were trying out stuff with telomeres, still true?

Hopefully he doesn't go the Bill Gates route of making grand dystopian plans for humanity.

>>18192665
>And if we are already at it, disguising fear of death as science or progress is disgusting and repulsive even for you anons.
And yet you take vaccines and receive medical treatments that didn’t exist four hundred years ago and have no qualms with it, two-faced kike.

>>18191586
He's slowly turning into a man

>>18192610
>immortal out-of-touch boomer bosses
>wagie's great-grandkids work for the same old bastard
>he will sexually harass every young female in your entire lineage
can't wait

>>18192657
Funding is a good start but it doesn't mean much when 90%+ of the field is fraud.
Research didn't increase much in that timeframe, what gave you a different idea?
Of course I know these guys, since they're everyone's favorite maymay, that's like naming schmidhuber and bengio in deep learning, respectively, except schmidhuber actually knows what he's doing despite his stupidly loud mouth and attention crave. Unlike schmidhuber, de grey is one of the aforementioned 90%. At least name borderlines like botstein next time.
Telomeres have been another epic maymay that's been peddled for decades and hasn't led to anything at all to this day. Even if they were relevant, going after telomeres at the telomere level instead of at a higher level (rna/protein expression and regulation) would be infinitely more productive.
There has been no real progress for decades and no promising new approaches. The science of aging itself has barely progressed at all, and almost no result can be trusted (though that's biology in general - NMR and phylogeny aren't any better in that regard).

>>18191586
If I'm 22 can I reasonably have my age reversed in my lifetime?
Living forever in an old man's body does not sound that appealing

>>18192826
Don't worry, keep working hard another 50 years and you'll get a new dose of anti-aging serum! Whenever you want it or not.

>>18192694
That will always be true. In 1000 years (when we'll almost certainly have proper life extension to speak of, if not outright immortality), they'll still be trying, just watch.

When there is there's no fucking way it will be available to anyone except the top 1% of wealth and power

Our job is to go to school, learn a societal role, work in that role/role(s), when we can no longer work or produce then quickly dropping dead is favourable, that would please the overlords greatly

They don't want worker drones existing 160+ years living their best lives,

Also imagine the overpopulation problem that will also bring along

>>18192677
>I don’t want to be stuck in space and time any longer than I have to

Do I even have to say it?

>>18192866
thoughts on this?

https://www.biorxiv.org/content/10.1101/710210v1

want eternal life? turn to CHRIST

>>18192677
>As for me I don’t want to be stuck in space and time any longer than I have to
Then simply kys

>>18192874
Yes. If the body can sustain itself and repair damage, it can almost certainly reverse ageing and turn an old person back into looking young again.

>>18191586
Godless heathens dare try to achieve immortality. It is the ultimate sin, and they shall pay dearly.

>>18192874
I think it’s happening in the next 40 years. It is going to explode this decade at the research level. There’s a reason Vitalik is posting this shit.

>>18192665
>covid 69
yell me more about this covid 69 anon, it happens to he my favorite number if you know what I mean

>>18191586
Last thing we need is even more old people

>>18191586
what a faggot
dying is the most redpilled thing a person can do

>>18191586
>The boomer refuses to die with dignity and honor, instead dies pleading for the fountain of youth to further prolong it's miserable existence.

>>18191586
This nigga just called your grandma a burden to society and your family.

>>18191586
lol this nigga thinks he's gonna live forever

>>18191586
This will happen naturally as medical science advances. "Aging research" is just a scam. In the quest to cure all infectious disease, cancer and heart disease we will find a solution to aging. It is inevitable.
Immortality on the other hand, is probably not attainable or desirable. The fact that we die if we cling to life for too long is one of Nature's rare mercies.

Life extension is not possible. You can’t stop the brain from aging. The brain will run out of memory eventually, too.

>>18193274
>REVIVE
Promising research, assuming it can be duplicated, but still... if only it were that simple. The number of things that could go wrong between what's described in that paper and actual systemic anti-aging genetic therapy is really fucking huge.

>>18191586
tfw rich but not rich enough to be in the tortured baby blood drinking club

>>18193274
>qpcr
>fucking ear fibroblast
>FUCKING FACS
>random choice of days for compared treatment because fuck you
>(((differentially expressed)))
>target gene expression
I'm also fairly sure their choice of genes is misplaced. klf4 is involved in thymic convolution and has increased activity post-partum including in murine models regardless of mouse age in thymic epithelial cells, so saying its expression level is relevant in the study of aging is not necessarily well-supported (the same apply to the other genes, the reason I only mention klf4 is that it's a relatively new result). It's known to be related to regeneration, but says nothing about aging, and while there is a correlation between pregnancies and lifespan, it's quite far from statistically sound life extension and hasn't been observed to hold in humans. Additionally, signature-based approaches (like here with the yamanaka tfs) has shown to be sketchy on its own. For example, in cancer research, every other group has their different signature for so or so cancer, with 0 overlap with other groups' cancer markers, and every time they're all exactly as predictive. Other research has shown that picking 50 genes at random and using them as a marker is enough to get strong predictive power for cancer type in tcga data.
They also claim that OSK restores gene expression (of just 464 genes with rather poor correlation with OSK vs aging) to youthful levels but that's clearly NOT what the data shows (see 11b) and there's 0 correlation between OSK and the methylation clock, which in turn is consistent with aging, = OSK is not anti-aging (see fib 7c).
Overall, it's bad aging research using antiquated tools well reputed for their lack of accuracy with tenuous methodology and poor analysis, a classic example of the typical level of the larger field (i.e. it's really good when compared to the specialized aging research field, that's how shit most aging research is). Not to mention, few replicates.

>>18194199
What they found is... nothing anyone didn't already know (although the further evidence for klf4's involvement in post-partum thymus regeneration is cool I guess), but they tried to shoehorn aging into it while their data clearly demonstrated no relation between the two.

the coming of life extension technology will be the beginning of the end

absolute idiots

>>18193868
Bro I'm 30 and I'm already running out of memory. Fortunately you don't really need to remember that much to get by in society though.

fucking based

>>18191586
>Let's reverse human entropy

Imagine being so autistic about computers shit that you are literally retarded about all things human related.

>>18191586
Honestly, this is based as fuck. Longer life is a side-effect of health.

Maybe get people to stop reproducing so much before you think about extending lives.

>Master, vitalik wants to achieve quantum immortality
>ACTIVATE COVID-19 stage II

>>18191879
There are companies working on this. Check out agex. Early stage though.

>straps your political prisoner to a chair
>torture him to brink of death
>heal him back with life extension technology
>repeat forever until he gives up information
>leaves him to be tortured for decades/centuries for fun anyway

if such a technology ever becomes possible it will be a weapon

>>18194505
Yes, I know. The problem is that they're very few and far between.

life is both a gift and a curse

living forever is hell

>>18194507
>they could have just scanned your brain but decided not to

i don't know what's worse

>>18194529
Apply bullet to head, problem solved even if you're biologically immortal.

>>18191586
all that would happen is skyrocketing rates of suicides

>>18194529
You whiners in this thread just dont want to get your hopes up because you fear you will be disappointed. Sour said the fox about grapes. Can always kys if 1 million years of life gets boring. Would still be nice to have that choice to live long.

>>18194199
Thanks for the blackpills anon, maybe I’m being overly optimistic. You don’t see even modest breakthroughs happening in the next 30 years? It just seems like this field is exploding the past couple years. Surely they could give us gap treatments that tack on 10-15 years? What about Alzheimer’s? Will it be cured in 30 years?

>>18194199
nigga just spoonfeed me, I don't got time for all this fancy talk.

What substances can I insert into my body today to gain a longevity advantage? Is calorie restriction still the only tried and true 'drug'?

>>18194917
I unironically just want to see the futuristic vidya and VR that will exist 100 years from now

>>18195013
Stem cells from young people, check out athersys.

>>18191586
You think this hasn't been continuously worked on by the rich cunts that rule over us?

>>18192866
>90%+ fraud
cool. that's what i figured.
so are senolytics bullshit? (although the concept is intriguing)
and is caloric restriction still the only thing that seems to work?

>>18191586
Isn't Google Calico conducting aging research?

>>18193673
>>18193752

So many brainlets ITT. Life extension =/= immortality. I accept that I am going to die but it would be cool to get a couple of extra years of life to see what crazy shit unfolds on this planet and what technology and entertainment is created.

>redpilling
Cringe

It's always a certain kind of person that wants to live forever and it won't be happening any time soon

>>18192555
No it's because of relativity. You have more previous experiences measured in units of time to compare to. The first year of your life is the longest because you have never experienced the length of a year before. That first year is 100% of your life experience. If you lived 100 years, 1 year is only 1% of your life experience. The more years you experience, the shorter they "seem" to be. Time does not speed up, It's just your perception of it changes.

>>18192610
They probably won't make it. Too old already to be saved once this gets applied.

>>18191586
what is "based" about this?

>>18192665
It's just cope anon. Like religion, created to ease anxiety over our impending death so we can function in the present.

>>18193011
De Grey touches on this. It would be cheaper to have people healthy and continue to work then draining the healthcare care/pension systems with retirement. Governments would have to pay for it.

>>18196322
>Cringe
cringe

>>18196358
Take a wrong turn? BSV thread is over there

>>18196330
That perception can be altered though. I’m not sure why people itt don’t realize it. Retarded to think we’ll figure out how to live a thousand years but won’t figure out anything about controlling how quickly we experience it

>>18196477
what a retarded post

>>18196409
If it's so much cheaper why do govts have to pay for it? Wouldn't companies with good workers want to keep them alive? Wouldn't insurance companies want to reduce claims, and wouldn't pharmaceutical companies want to sell them drugs (and extend their lifetime customer value by another few centuries)?

>>18191586
Adrenochrome
Bearish

who gets the drug? age limit? parents force kids to take it? overpopulation booms. I think we're meant to die. there has to be something else out there beyond death. the double slit experiment has implications regarding consciousness being a separate entity in itself and reality being a binary process. on off states. the physical vacuum storing your data. when your computer heats up from working it's releasing deleted 1's and 0's into the aether as pure base information. all these rockefellers ruling the world would be living forever if it were possible, yet they seem to be okay with death, not phased by it. I wonder why

>>18196498
You would have to erase memories. The more time you experience, the smaller portion the present is of your total experience. You can't change relativity.

>>18196409
de grey is a fraud lol watch the first 10 minutes of the rogan interview he just did. literally bro science tier.

>>18194464
Stage II juste before the elections

>>18191696
>thinks anti aging will ever be a thing
>even if it becomes a thing, he thinks the masses will have access to it
>calls others normies
go jump off a bridge you fucking retard

>>18196571
Take psychedelic mushrooms and see if you still believe that. Adult perception of time can be drastically altered I've experienced it first hand.

>>18196521
kys craig

>>18196733
you’d have to be a special kind of retard to think (((they))) would turn down the opportunity to cut healthcare costs into ribbons and have a cheap workforce that never gets replaced

>>18196842
what the fuck is wrong with you faggot? i only asked why is that based. what the fuck does craig or bsv have to do with anything itt? christ
unironically kys you little bitch

>>18191586

Wow, he is literally a narcissistic degenerate.

Cellular repair is unsolvable in principle, the whole evolution failed to solve it.

Of course, it is endless opportunity of bullshitting and cosplay of way above average intelligence while others invest in you.

But no, entropy can't be solved by narcissistic degenerates.

>>18196842
That's an interesting point and I believe psychedelic's can alter time perception but is it not temporary? Perhaps those changes could be made more permanent.

>>18197048
Evolution is not making conscious decisions. Cellular repair was not prioritized in primates because there hasn't been an environmental pressure to do so. Other organisms are biologically immortal.

>>18196572
He doesn't even say anything the first 10 mins. Just the kind of beer he drinks. Say what you want about the guy but he has completely revamped the anti-aging industry. It was a complete joke before him and no one even knew it existed. Now even people like you are familiar with it.

>>18191586
>If I stay in a hospital bed forever maybe can dodge hell and continue raping kids.

>>18191586
nah fuck old people. They all deserve to die

>>18191586
>mfw holding 500k PNK is literally extending my life because all stress is gone and I am just comfy now

For anyone concerned about live becoming meaningless. Just wrote your best memories down and wait until you can delete clutter. You got time now!

>>18196572
He talks to normies and pros differently, like he should.

>>18191586
This faggot is worse than Trump when it comes to twitter

>>18191586
YEAH LETS DISRUPT THE CYCLE GOD PUT IN MOTION AND INSTEAD LETS MAKE IT SO EVERYONE CAN SLAVE FOR JEWS FOR 200 YEARS EACH AND THE POPULATION CAN BOOM FOREVER SURELY NO CONSEQUENCES UNFORSEEN WILL RESULT

>>18196214
Well this is why we have fda and clinical trials, to weed out fraud.

>>18197166
he definitely does, talks about how he doesn't need to excersise and he drinks daily, etc. people like you bought the bullshit unfortunately

>>18197260
cope

>>18194917
you act like things always work as intended

if such a feat ever becomes possible it will be used as a weapon first before it ever reaches the public

>>18194507
Immortality opens the possibility of real hell on earth. You could keep an organism tortured alive in darkness forever.

Until we achieve psychic communication, we shouldn't pursue true immorality. Anti-aging is fine though.

>>18197340
That is not talking about biology you absolute brainlet. And he's right though. The man is 57 years old, 0 Male pattern baldness, not obese at all, no diabetes, blood pressure, etc. All this from drinking everyday and eating what he wants. Most burgers will not even make it to 40 without having problems.

>>18191586
Vitalik is too smart the normies won't get it.

>>18191879
>>18191696
The "Anti-Aging" ointments are just way for rabbis to sell their foreskin bags.

>>18197944
HAHAHAHHAHAHA

>>18194505
agex is bringing products to market. they've been working for 30 years. i wouldnt say they're early days by any means.

>>18191789
this idiot scammer is in here

>>18192555
Smoke some weed

>>18191789
missing 'still drinks like a fish'

Snake oil salesman

>>18197048
>Cellular repair is unsolvable in principle, the whole evolution failed to solve it.
Huh? Plenty of organisms can repair themselves anon

you guys are all taking this wrong. they are going to give us cyborg bodies without balls.

Immortality is population control win win.

Dude is major in biology. Only realistic immortality in the next 50 years is Elon Musk Neuralink and Universal Neural Stem Cells. It pisses me off when Elites think throwing money at projects that do not involve cutting your brain out and keeping it solely alive will work. The body is way to complex.

>>18192398
Are you me?
This is also my end goal. I also didn't continue in biology because I figured out you don't get to chose what you work on. I went law to try and end that dated ethical bullshit holding science and testing/experiences back.

>>18191586
Age reversal / extension will never happen. Humans are going extinct from climate change this century, society will collapse in the next 10 years.

>>18192677
What a lack of imagination.
Plenty of things to see out there Anon, the world is huge.

old news, there's already promising anti-aging solutions via young plasma transfusion into elderly folks. how do you think ruth bader ginsberg is still alive.

>>18199217
>society will collapse in the next 10 years.

>>18196898
Bsv is for low iqs and yours is showing
Run along now

>>18191789
Did de Grey actually sign up for cryonics?

>>18199196
How do you do that as an attorney? What is your practice and how do you make money? I’d actually be interested on working on this.

>>18199196
How do you do that as an attorney? What is your practice and how do you make money? I’d actually be interested on working on this.

>>18191586
Who would want to live forever in clown world?

>>18191696
Just how the fuck would you "age-reverse" any living human. You would have to genetically engineer a new form of life.

>>18191586
So when will ETH moon>?

>>18191586
Vitalik stop spamming your retarded twits here. You are irrelevantm cringe, and skelly

>>18198502
no shit, you can spot him easily by the way he types every time a hex thread comes up

>>18191586
>lets end aging
I wish Skelly would stop with these facetious low-IQ takes. Build something.

Jews would not let you dumb goyim have any decent life extension tech. Besides there’s plenty of other reasons why it’s retarded and not possible in this thread.

Rev 9

6 And in those days shall men seek death, and shall not find it; and shall desire to die, and death shall flee from them.

>>18191586
What an idiot.

learn what redpilling means faggot, don't ever post here again

>>18194199
Thanks anon, very interesting stuff

>>18193794
it is time for more... experiments

>>18192610
The way its going to anti-aging pill will come right when they'll be boomers and own everything.
Zoomers will inherit the earth for eternity.

>>18194999
In 30 years, there will almost certainly be at least 2-3 minor breakthroughs, but you need many of these to work toward a meaningful milestone. For example, it's probable that we can find how to extend a human lifespan by 5 years or so within 30 years, but until such a time that we can extend lifespans by more years than it takes for the next breakthrough, it's not really meaningful.
An endemic problem to aging research is that you can't just do standard clinical trials since it's obviously not viable to wait 80-100 years to see if treatment worked so the field will always have issues with grand claims and little proof anyway.
>>18195013
Continuing from above, calorie restriction and red wine, and "living in a blue zone" (because we have no clue what's special about people in blue zones so we have to assume it's environment, but we don't know which part of it, so do as the romans do) may or may not work, and doing all 3 could maximize your chances of seeing an effect, but for now there's nothing convincing at all.
>>18196214
>so are senolytics bullshit?
To my knowledge there is no proven working true senolytics. It's the same as the yamanaka tfs: things that may or may not help some metric of health in mice (no proof of it working in humans), and then handwavy "it's totally the same as reversing aging" shit, and even then current senolytics only work on select parts of the body.
I also think the approach is naive. The alleged process is aging -> increased failure to remove senescent cells -> several bad things that may be consistent with aging-related conditions, and the proposed solution is to treat, therefore, an intermediary symptom rather than the cause.
All these things, as always, require more research, which includes more funding but also less fraud. We can't properly say for most proposal that "they are useless/don't work" but only that "they don't work at present" or "there's no evidence it could help, yet".